A Manual of Materia Medica
and Pharmacology
by David M. R. Culbreth, Ph.G., M.D. (1927)
Lactuca
Lactu'ca viro'sa, Lactucarium, Wild Lettuce.
-- The dried milk-juice, U.S.P. 1820-1910; C. and S. Europe. Biennial
herb .6-2 M. (2-6 degrees) high, glabrous, green, often purple spotted;
leaves runcinate, radical and cauline, spinous apex and margin, auriculate,
glaucous-green, flowers yellowish, milk-juice (lactucarium) usually in
quarter sections, angular pieces, brownish, fracture tough, waxy; internally
light brown, porous; odor distinctive, opium-like; taste bitter.
Powder, brownish--irregular fragments without cellular structure.
It is obtained by cutting off the head of each stalk and scraping the exuding
juice into small vessels, repeating the process 6-7 times daily for several
weeks, each cut being made a little lower down the stalk; by night, having
become a viscid mass, it is divided into suitable pieces and dried by gentle
artificial heat for 5 days, losing 75 p.c. in weight; solvents: water (51
p.c.), diluted alcohol (36-44 p.c.), spirit of chloroform (55-60 p.c.),
being mostly lactucerin (lactucon) 50-60 p.c., lactucin, lactucic
acid, lactucopicrin, caoutachoue, resin, volatile oil, ash 10 p.c.
With water--turbid mixture; + iodine T.S. -- not colored blue (abs. of
starch); + ferric chloride T.S. -- only faint green (abs. of tannin).
There are three varieties: 1, English; 2, German; 3, French (Aubergier's).
The juice of L. Sati'va, obtained like lactucarium, yields Lactucarium
Gallicum, and when expressed from the stalks, clarified by coagulation,
expressed and inspissated -- Thridace. Anodyne, sedative, hynotic,
diuretic, expectorant, very unreliable; milder than opium, and unlike it,
does not derange the digestive organs; where opium is objectionable --
to procure sleep, allay cough, dropsy, palpitation of heart, nervousness.
Dose, gr. 1-8 -- 15 (.06-.5 -- 1 Gm.): Tincture, 50 p.c., dose, 3ss-1 (2-4
cc.); Syrup, 5 p.c., dose, 3j-4 (4-15 cc.; Fluidextract, dose, mj-30 (.06-2
cc.); Lozenge. L. Canaden'sis (elonga'ta), Wild Lettuce, U.S.P. 1820-1840.
The herb; N. America, rich damp soil, fields, thickets; herb 1.3-3M. (4-10
degrees) high, hollow, purple leafy, glaucous; leaves 15-30 Cm. (6-12')
long, pinnatifid; flowers yellow to purple, heads 20-flowered, panicles.
Juice from plants in flower make good lactucarium, that collected in early
season being without bitterness. L. Sati'va, Garden Lettuce, yields
a juice that is medicinal and more abundant in wild than cultivated plants;
highly valued as salad and as such is a feeble hypnotic. L. Sagitta'ta
(altis'sima), large Caucasian plant 2.5-3 M. (8-10 degrees) high, chiefly
cultivated in France.
Laurus
Lau'rus no'bilis, Laurel, Sweet Bay. -- The
leaves and fruit; Mediterranean Basin. Leaves 5-10 Cm. (2-4') long,
pellucid-punctate, smooth, aromatic, astringent; fruit (bayberries) oval
drupes 12 Mm. (1/2') long; contain volatile oil, fixed oil (Oleum Lauri)
30 p.c.; stimulant, astringent, stomachic.
Lavandula
LAVANDULA. LAVENDER.
Oleum Lavandulae. Oil of Lavender, U.S.P.
Lavandula spica, Linne'. A volatile
oil distilled from the fresh flowering tops, yielding not less than 30
p.c. esteres, calculated as linalyl acetate.
Habitat. S. Europe (France, Italy,
Spain), N. W. Africa -- sunny hills and mountains; cultivated.
Syn. True (Garden, Spike, Common) Lavender,
Flores Lavandulae; Fr. Lavande Vraie, -- officinale; Ger. Lavendelbluten;
Ol. Lavand, Oleum Lavandulae Florum, U.S.P. 1900; Fr. Essence de
Lavande; Ger. Lavendelol.
La-van'du-la. L. fr. laso, lavare,
to wash -- i.e., medieval name, in allusion to the use made of its
distilled water for bathing.
Spi'ca. L. Spica, a point, spike --
i.e., flowers arranged in a spike: terminal cluster.
PLANT. -- Shrub .3-1 M. (1-3 degrees) high; stem
crooked, branched, bark brownish-gray, much cleft when old; leaves linear,
sessile, entire, revolute margins, with whitish down, crowded at bases
of the quadrangular branches; flowers June-July, lilac-color, terminal
spikes, 2-lipped, hairy, glandular; entire plant delightfully fragrant.
CONSTITUENTS. -- Volatile oil 1-3 p.c., resin, tannin.
Oleum Lavandulae. Oil of Lavender.
-- A colorless, yellow liquid, characteristic odor and taste of lavender
flowers, soluble in 3 vols. of 70 p.c. alcohol, sp. gr. 0.881, levorotatory;
contains a terpene, C10H16, 2 alcohols -- geraniol,
C10H18O, and (chiefly) linalool, C10H18O,
also, its compound ester -- linalyl acetate, C10H17C2H3O2,
30-36 p.c., upon which the value depends, and a little cineol -- a large
quantity of this latter proving the presence of oil of spike (wild broad-leaved
variety). When cold deposits stearoptene, and if distilled from leaves
and stalks the odor is more rank. Tests: 1. Shake in a narrow glass
cylinder with equal volume of distilled water--volume not diminished (abs.
of alcohol). The French oil is from flowers, sometimes including
leaves, of wild plants collected July-Sept., the late and high altitude
products being best -- chief commercial article; the English oil (oil of
garden lavender) is solely from flowers of cultivated plants, the yield
being small and price high. Should be kept cool, ark, in well-stoppered
amber-colored bottles. Dose, mj-5 (.06-.3 cc.).
ADULTERATIONS. -- Oil of turpentine -- less soluble
in alcohol; oil of sweet basil (Oc'imum Basil'icum), Asia, Africa -- plant
cultivated in gardens for seasoning food and for its white or reddish flowers;
oil balsamic, aromatic, possessing a cooling taste.
PREPARATIONS. -- 1. Spiritus Lavandulae. Spirit
of Lavender. (Syn., Sp. Lavand.; Fr. Alcoolat (Esprit, Eau) de Lavande;
Ger. Lavendel-spiritus.)
Manufacture: 5 p.c. Dissolve oil 5 cc. in alcohol q.s.
100 cc. Dose, 3ss-1 (2-4 cc.).
2. Tinctura Lavandulae Composita.
Compound Tincture of Lavender. (Syn., Tr. Lavand. Co., Compound Spirit
of Lavender, Lavender Drops; Fr. Teinture de Lavande composee; Ger. Zusammengestzte
Lavendeltinktur.)
Manufacture: 4/5 p.c. Similar to Tinctura
Cardamomi Composita, page 137 -- using oil of lavender .8 cc., oil of rosemary
.2, cinnamon 2 Gm., clove .5, myristica 1, red saunders 1, macerating powders
in alcohol 75 cc., in which the oils have been dissolved, and water 25
cc., finishing with 75 p.c. alcohol. Dose, 3ss-1 (2-4 cc.).
Prep.: 1. Liquor Potassii Arsenitis, 3 p.c.
(arsenic trioxide 1 p.c., potassium bicarbonate 2 p.c.).
3. Linimentum Saponis Mollis, 2 p.c.
4. Spiritus Ammoniae Aromaticus, 1/10 p.c. 5. Unguentum Plumbi Oleatis,
1 p.c. 6. Acetum Aromaticum, N.F., 1/20 p.c. 7. Mistura Oleo-Balsamica,
N.F., 3/5 p.c. 8. Oleum Hyoscyami Compositum, N.F., 1/5 p.c.
9. Petroxolinum
Liquidum, N.F., ½ p.c. 10. Petroxolinum Spissum, N.F., 3 p.c.
11. Spiritus Odoratus, N.F., 2/5 p.c.
Unoff. Preps.: Water, 1/5 p.c. Infusion
and Fomentation (flowers).
PROPERTIES. -- Stimulant, carminative, nervine,
errhine.
USES. -- Gastralgia, nausea, flatulence, to correct
nauseating medicines, nervous headache; mostly in perfumery.
Flowers, U.S.P. 1840-1880. Oil of Lavender
Flowers, U.S.P. 1880-1900, distilled from the fresh flowers. L. Stae'chas.
Arabian (French) Lavender, has dark purple flowers aromatic camphoraceous
odor, and is used with other varieties for obtaining the oil.
Limonium
Limo'nium carolinia'num (Stat'ice Limo'nium var.
Carolinia'na), Marsh Rosemary. -- Plumbaginaceae. The root, U.S.P.
1830-1870; N. America. Plant a maritime perennial, acaulescent; leaves
2.5-4 Cm. (1-1 3/5') long, obovate, cuneiform, entire, mucronate, scape
.3-.6 M. (1-2 degrees) high, terete, corymbose panicles; flowers lavender
color; root .3-.6 M. (1-2 degrees) long, 2.5 Cm. (1') thick, annulate,
wrinkled, purplish-brown, astringent, bitter; contains tannin 14-18 p.c.,
volatile oil, resin. Astringent like catechu or kino; aphthous and
ulcerative affections of the mouth, fauces, hemorrhages, dysentery; in
decoction, infusion, tincture. Dose, gr. 5-30 (.3-2 Gm.).
Lindera
Ben'zoin (Lin'dera) Benzoin, Spice or Benjamin
Bush. -- N. America, damp woods. Shrub 2-4.5 M.( 6-15) degrees)
high, smooth; bark mostly used, berries and leaves to some extent; tonic,
aromatic stimulant, diaphoretic; berries for allspice. Dose, gr.
15-60 (1-4 Gm.).
Linum
LINUM. LINSEED, U.S.P.
Linum usitatissimum, Linne'.
The dried ripe seed with not more than 2 p.c. other seeds or foreign organic
matter, yielding not less than 30 p.c. non-volatile, ether-soluble extractive
-- 98 p.c. being saponifiable.
Habitat. C. Asia, Egypt, S. Europe,
spontaneous in most temperate countries; cultivated in Russia, Egypt,
India, United States, S. Europe, England, Holland.
Syn. Flaxseed Flax, Lint-bells, Winter
lien; Br. Lini Semina, Lini Semina Contusa (Crushed); Fr. Lin, Semence
(Graine) de Lin; Ger. Semen Lini, Leinsamen, Flachssamen.
Li'num. L. See etymology, page 330,
of Linaceae.
U-si-ta-tis'si-mum. AS. fleaz, flechten,
to braid, plait, twist -- i.e., its fibers, + seed.
PLANT. -- An annual; stem .6 M. (2 degrees) high,
stiff, erect, solitary, round, smooth, green; leaves small, lanceolate,
acute, entire, sessile, pale green, 2-4 Cm. (4/5-1 3/5') long; flowers
June-July; terminal, bluish; fruit August, globular capsule, size of pea,
with persistent calyx at base, crowned with sharp spine, 10-seeded in distinct
cells. SEED, ovate, oblong-lanceolate, flattened, obliquely pointed
at one end, 4-6 Mm. (1/6-1/4') long, brown, smooth, shiny, raphe a distince
yellow ridge along one edge, hilum and micropyle in depression below pointed
end; internally light yellow, brownish; odor slight; taste mucilaginous,
oily. POWDER, yellowish-brown -- large oil globules, irregular fragments
of endosperm and seed-coat, the latter with pigment cells filled with brownish
insoluble contents, stone cells with porous walls, aleurone grains.
MEAL (ground, lini farina, crushed linseed), yellow with numerous brown
coarse fragments -- seed-coat and kernel. Test: 1. Boil 1 Gm. fat-free
powder or meal with water 50 cc., cool -- filtrate + iodine T.S. not more
than faint blue (abs. of starch or starch-bearing seeds). Solvent:
boiling water. Dose, 3j-2 (4-8 Gm.).
ADULTERATIONS. -- SEED: Foreign seeds and earthy
matter 1-25 p.c. -- mustard, rape and other cruciferous seeds, sand, small
stones; POWDER: Damaged flour, cornmeal, other starchy substances, recotnized
by microscope or iodine test; expressed cake and tht to which mineral oil
has been added.
Commercial. -- The flax is of ancient origin,
being prized for its fabric and medicinal properties; most of our seed
now come from Russia and Germany, but the United States furnishes considerable.
When exposed to heat, light, damp atmosphere, or otherwise carelessly preserved,
especially the ground, it is subject to insect attack, and should not be
used after 1 year old.
CONSTITUENTS. -- Fixed oil 35-40 p.c. (in nucleus),
Mucilage, C12H20O10, 15 p.c. (In integuments--viscid,
odorless, nearly tasteless, precipitated by alcohol, lead subacetate, but
not by tannin), proteins 25 p.c., tannin, amygdalin (resin, wax, sugar,
no starch (except in young seed), ash 4-6 p.c.--phosphates sulphates, chlorides
of potassium, calcium, magnesium.
Oleum Lini. Linseed Oil, U.S.P. --
(Syn., Ol. Lini, Oil of Flaxseed, Raw Linseed Oil; Fr. Huile de Lin; Ger.
Leinol, Leinsamenol.) This fixed oil, usually obtained by drying
the seed with heat, crushing, and expressing, is a yellowish, oily liquid,
peculiar odor, bland taste; gradually thickens and darkens on exposure,
acquiring a pronounced odor and taste; slightly soluble in alcohol, miscible
with ether, chloroform, petroleum benzin, carbon disulphide, oil of turpentine;
slightly acid; sp. gr. 0.930, congeals at -20 degrees C. (-4 degrees F.);
consists of liquid glycerides of oleic acid, C18H30O2(5),
linolenic acid, C18H30O2(15), and isolinoleic
acid, C18H32O2(65) 85-90 p.c., also a
mixture of palmitin, myristin, and stearin 10-15 p.c.; also claimed to
consist chiefly of linoleic acid, 22-25 p.c. of linolenic acid, and 5 p.c.
of solid fatty acids; 1 p.c. of non-saponifiable matter. Linolein,
the glyceride of linoleic acid, is considered the drying constituent, which
on exposure is converted into oxylinoleic acid hydrate, and finally into
linoxyn, C32H54O11 (insoluble in ether,
and soon forms in the boiled oil). Yield by cold process 16-20 p.c.,
by heat 25-28 p.c., the latter being darker, with stronger odor and more
acid taste. Tests: 1. Linseed oil spread in thin layer on glass plate
forms a hard, transparent film (abs. of non-drying oils). 2. Add
3 Gm. Potassium hydroxide to oil 10 cc. + alcohol 10 cc. + distilled water
10 cc., heat on water-bath until clear; the addition of distilled water
100 cc. -- clear solution, free from oily drops (abs. of mineral or rosin
oils). 3. Oil 2 cc. + glacial acetic acid 2, agitate, cool, add sulphuric
acid 1 drop -- greenish color (abs. of rosin or rosin oils, which produce
a violet color). Impurities: Free acid, non-drying oils, mineral
or rosin oils, rosin. Should be kept in well-stoppered containers,
and that which has been "boiled" must not be used or dispensed. Dose,
3ss-2 (15-60 cc.).
PREPARATIONS. -- SEED: 1. Species Emollientes, Emollient
Cataplasm, N.F., 20 p.c. OIL: 1. Sapo Mollis. Soft Soap.
(Syn., Sapo Moll., Sapo Viridis, Green Soap; Fr. Savon (mou) vert; Ger.
Sapo kalinus, Kaliseife, Grune seife.)
Manufacture: Boil, stirring frequently, dekanormal
solution of potassium hydroxide 29 cc. and sodium hydroxide 110 with linseed
oil 400 and water q.s. 925, add glycerin 50 cc., boil until clear, add
hot water q.s. 1000 Gm., let stand, stir until water absorbed. It
is a soft, unctuous, yellowish-white mass, slight characteristic odor,
alkaline taste; aqueous solution alkaline; solution in hot distilled water
(1 in 20) nearly clear.
Preps.: 1. Linimentum Saponis Mollis.
Liniment of Soft Soap. (Syn., Lin. Sapon. Moll., Tincture of Green
Soap, Spiritus Saponis Kalinus Hebra; Fr. Teinture de Savon vert; Ger.
Hebra's Seifenspiritus.)
Manufacture: 65 p.c. Mix oil of lavender
2 cc. with alcohol 30, add soft soap 65 Gm., stir or agitate until dissolved,
set aside 24 hours, filter, add alcohol q.s. 100 cc.; used externally.
2. Linimentum Calcis, 50 p.c.
3. Liquor Cresolis Compositus, 35 p.c. 4. Ceratum Resinae Compositum,
Deshler's Salve, N.F., 13.5 p.c. 5. Pasta Zinci Mollis, N.F., 25
p.c. 6. Petroxolinum Sulphuratum, N.F., 37 p.c.
Unoff. Preps.: SEED. Infusion, 5 p.c.
Compound Infusion, 5 p.c., + glycyrrhiza root 2 p.c. These were once
official and are effective from the dissolved mucilage of the epithelium
(testa), which is altered starch. Dose, ad libitum. Decoction,
5 p.c. Poultice.
PROPERTIES. -- Demulcent, emollient, diluent, diuretic.
USES. -- Infusion or tea for inflammation of mucous
membranes of respiratory, digestive, and urinary organs, renal and vesical
irritation, catarrh, dysentery, calculi, strangury. Decoction, owing
to the oil it contains, is less acceptable to the mouth, but all the better
for enema. Poultice of ground meal to enlarged glands, swellings,
boils, pneumonia, etc., made by adding boiling water to meal for proper
consistency and bringing to a boil. Should coat skin with glycerin,
olive or other oil before applying, and place as near to affected spot
as possible; may cover with oiled silk to retain heat and moisture, and
may add olive oil, lard, laudanum or any anodyne, stimulating, or astringent
solution to poultice. The oil is laxative (3j; 30 cc.), excellent
in piles (3j-2; 20-60 cc. night and morning); sometimes it is added to
purgative enemata, also to cover erysipelatous and irritated skin surfaces,
but with the disadvantages of soon drying (thus rendering skin stiff) and
becoming sour and irritating. The linimentum calcis is applied to
recent burns to allay irritation.
Allied Products:
1. Flaxseed Cake, Oil-cake. -- Flaxseed when
ground yields cake-meal, and this, after being deprived of oil, becomes
oil-cake; it still contains all of the nitrogen, 4-5 p.c., and, moreover,
a little oil, thus serving well as a cattle food; yields ash 5-8 p.c.
2. Boiled Linseed Oil. -- Obtained by heating
oleum lini to 130 degrees C. (266 degrees F.), while passing a current
of air through it, when it boils, losing 6-8 p.c. by weight; or may heat
and add litharge, red lead, manganese dioxide, lead acetate or manganous
borate, thereby increasing the oil's weight and drying properties.
It is darker in color, thicker, sp. gr. 0.939-0.950, and dries faster,
hence useful in painting, varnishing, etc., but must never be used in liniments
as a substitute for the official ("raw") oil, since irreparable injury
(from forming crusts) might be occasioned to burns, etc., in removing dressings.
3. Flax Liber-fibers. -- These furnish linen,
which, when scraped, gives lint, while the primitive short fiber is useful
as tow.
Liquidambar
STYRAX. STORAX, U.S.P.
Liquidambar orientalis, Miller, Styraciflua,
Linne'. A balsam obtained from the trunk.
Habitat. 1. Asia Minor -- Southwestern
portion near coast, forming entire forests; 2. United States -- Atlantic
coast southward.
Syn. Liquid Storax; 1. Levant Storax;
2. American Storax, Copalm Balsam; Oriental Sweet Gum, Storax Tree;
Gum Tree, Sweet Gum, Alligator Tree, Lordwood; Br. Styrax Praeparatus,
Prepared Storax, Balsamum Styracia; Fr. Styrax liquide (purific, depuratus);
Ger. Styrax depuratus, Gereinigter Storax.
Liq-uid-am'bar. L. liquidus, liquid,
fluid, + Ar. ambar, amber -- i.e., the color or fragrant, terebinthinate
juice or resin (balsam) resembles liquid amber.
O-ri-en-ta'lis. L. oriental, pertaining
to the Orient, or East -- i.e., its habitat.
Sty-ra-cif'lu-a. L. styrax, storax,
+ fluo, fluere, to flow -- i.e., storax sufficiently gluid at times
to flow or exudate.
Sty-rax. L. for storax, Gr., ..., altr.
of Ar. assthi'rak, sweet-smelling exudation -- i.e., a tree producing
it.
PLANTS. -- Trees 6-15 M. (20-50 degrees) high, resembling
maples; bark purplish-gray; leaves palmately 5-7-lobed, each division obscurely
3-lobed, 5-7.5 Cm. (2-3') long, 10-12.5 Cm. (4-5') wide, margin serrate,
bright green, smooth; flowers monoecious, in yellowish solitary heads;
fruit, globular capsule, 2.5 Cm. (1') broad, woody. BALSAM (storax),
a semi-liquid, grayish, grayish-brown, sticky, opaque mass, depositing
on standing a heavy dark brown layer (Levant); or a semi-solid, sometimes
a solid mass, softened by gently warming (American); thin layers transparent;
odor and taste characteristic; heavier than water and insoluble in it;
soluble (usually incompletely) in warm alcohol (1), also in acetone, carbon
disulphide, ether (some insoluble residue usually remaining). Tests:
1. 2 Gm. dried 2 hours at 100 degrees C. (212 degrees F.) -- loses
20 p.c. moisture. 2. Dissolve 10 Gm. in hot alcohol 40 cc. -- undissolved
residue 5 p.c.; evaporate filtrate -- yellow to brown residue 70 p.c. (purified
storax). Solvents: alcohol; ether. Dose, gr. 10-30 (.6-2 Gm.).
ADULTERATIONS. -- Turpentine, sand, ashes, bark,
mineral matter 13-18 p.c., water 10-40 p.c.
Commercial. -- The balsam is not a physiological,
but a pathological, secretion of the sapwood, existing only in injured
trees as a result of wound stimulation--Nature's method of securing antisepsis
and heaing. To obtain 1, Levant storax in quantity -- the outer bark
on one side of the tree is bruised, resulting shortly thereafter in filling
the cambium with rows of balsam glands and the inner bark with their exudation.
The dead outer bark is taken off and rejected, while the inner is removed
and boiled in sea-water -- the balsam being skimmed from the surface with
final expression of the boiled bark. It was once believed to be produced
in the inner bark, which was collected and thrown into pits, to allow partial
exudation, and ultimately subjected to pressure in strong horse-hair bags.
Liquid storax is then put into barrels, goat skins, etc., and forwarded
to Constantinople, Smyrna, Syria, Alexandria, Bombay, and Trieste.
To obtain 2, American storax -- incisions are made through the bark, or,
in the absence of these, during spring and summer, it exudates through
natural fissures, from which it may readily be scraped. The greatest
demand comes from India and China, the English-speaking people using little
of it. The residual bark when dried (Cortex Thymiamatis) is employed
for fumigation.
CONSTITUENTS. -- A variable mixture chiefly of volatile
oil, resins, cinnamic acid esters, and water -- Styrol, Styracin, Phenylproply
Cinnamate, Storesin, Cinnamic Acid, 5-15 p.c., benzoic acid, ethyl cinnamate,
C9H7(C2H5)O2, ethyl
vanillin, water 10-40 p.c., other impurities, ash 1 p.c.
Styrol, Styrene, Styrolene (Cinnamene,
Phynyl-ethylene), C8H8. -- Hydrocarbon (volatile
oil) obtained by distilling with water; it is a colorless fragrant oily
liquid, sp. gr. 0.906, boils at 145 degrees C. (293 degrees F.), and when
heated to 200 degrees C. (392 degrees F.) Is converted into solid metacinnamene.
Styracin, Cinnamyl Cinnamate, C9H7(C9H9)O2.
-- This is obtained in faint yellow crystals by alcohol, ether, or hot
benzene from the resin after removal of cinnamic acid; with concentrated
potassium hydroxide solution yields styrone (cinnamic alcohol), C9H10O,
yellowish oily refractive aromatic liquid.
Phenylpropyl Cinnamate, C9H7(C9H17)O2.
-- This is a thick inodorous liquid.
Storesin, C36H58O3.
-- This, the most abundant constituent, is amorphous, readily soluble in
benzin, melts near 145 degrees C. (293 degrees F.), or near 165 degrees
C. (329 degrees F.); the latter variety gives with potassium hydroxide
a compound crystallizing in needles.
Cinnamic Acid, C9H8O2.
-- Chiefly in free state, obtained by treating with solution of sodium
carbonate, precipitating with hydrochloric acid.
PREPARATIONS. -- 1. Tinctura Benzoini Composita,
8 p.c.
Unoff. Prep.: Ointment (salve), 50
pc., with lard or olive oil.
PROPERTIES. -- Stimulant, expectorant, diuretic,
antiseptic, disinfectant. Acts locallly and remotely like benzoin,
copaiba, balsams of Peru and tolu. Styracin is antiseptic, and should
be dissolved in 6-12 parts of oil or water to render it non-irritating
as a dressing.
USES. -- Chronic bronchitis and catarrhea, phthisis,
asthma. Externally in ointment as a detergent for indolent ulcers,
frost-bites, as a parasiticide for scabies, phthiriasis (pediculi), etc.
Allied Product:
1. Styrax Calamita. -- Resinous exudation
from Styrax officina'lis, in agglutinated tears resembling benzoin, wrapped
in leaves; a factitious variety consists of the ground, exhausted bark
or sawdust mixed with liquid storax, formed into reddish-brown cylindrical
cakes, brittle, friable, soft and unctuous to the touch; contains many
crystals of styracin, and has storax odor.
Liriodendron
Lirioden'dron Tulipif'era, Tulip-tree. --
The bark, U.S.P. 1820-1870; United States, China; tree 18-45 M. (60-150
degrees) high; flowers yellowish; fruit cone, 7.5 Cm. (3') long.
Bark in quills or curved pieces 2 Mm. (1/12') thick, purplish-brown, thin
ridges, inside whitish, smooth, astringent; contains volatile oil, resins,
liriodendrin, tulipiferine, tannin; injured by boiling. Used for
chronic rheumatism, dyspepsia, intermittent fever; in infusion or fluidextract.
Dose, 3ss-1 (2-4 Gm.).
Lobelia inflata
LOBELIA. LOBELIA, U.S.P.
Lobelia inflata, Linne'. The
dried leaves and tops with not more than 10 p.c. stems,nor 2 p.c. other
foreign organic matter, yielding not more than 5 p.c. acid-insoluble ash.
Habitat. N. America (Canada, United
States), in fields and open places.
Syn. Lobel., Indian Tobacco, Wild Tobacco,
Green, Brown, Bladder-podded Lobelia, Emetic Herb (Weed), Asthma
(Puke) Weed, Gag Root, Vomit Wort, Low Belia, Eyebright; Fr. Lobelie
enflee; Ger. Herba Lobeliae, Lobelienkraut.
Lo-be'li-a. L. after Matthias de Lobel,
Flemish botanist, physician, and author of several botanical works,
1538-1616, native of Lille, became physician and botanist to James I.,
died in London.
In-fla'ta. L. inflatus, inflated, swollen
-- i.e., seed are borne in egg-shaped inflated pod.
PLANT. -- Annual herb, .3-.6 M. (1-2 degrees) high,
erect, paniculately branched; stem cylindrical, coarsely and irregularly
furrowed, yellowish green, occasionally purplish, pubescent with numerous
spreading hairs; root fibrous. LEAVES, alternate, ovate, oblong,
2-9 Cm. (4/5 - 3 3/5') long, sessile or narrowing into a short petiole,
obtusely toothed, irregularly serrate-denticulate, each tooth with a yellowish-brown,
gland-like apex; pale green with scattered, bristly hairs; flowers blue,
long, loose racemes with short pedicles, calyx tube ovoid with 5 subulate
teeth, corolla tubular, 3-4 Mm. (1/8-1/6') long, 5-parted, the upper 2-lobed
portion cleft nearly to the base; stamens with anthers united above into
a curved tube enclosing the bifid stigma; capsules inflated, ovoid, ellipsoidal,
5-8 Mm. (1/5-1/3') long, light brown, inferior, enclosing numerous coarsely
reticulate seed; odor slight, irritating; taste strongly acrid. POWDER,
dark green, odor irritating -- fragments of seed-coat composed of polygonal
cells with thick yellowish walls; occasional elongated-conical, non-glandular
hairs; fragments of stem with tracheae having thickenings, pores, narrow
wood-fibers with thin, lignified porous walls; fragments of leaf epidermis
with elliptical stomata, pollen grains nearly spherical. Loses on
drying 75 p.c. Solvents; diluted alcohol; boiling water. Dose,
expectorant, gr. 1-5 (.06-.3 Gm.); emetic, gr. 10-20 (.6-1.3 Gm.).
ADULTERATIONS. -- Rare -- except its own stems and
roots.
Commercial. -- Lobelia was popular with the
North American Indians, but Dr. Cutler, of Massachusetts, introduced it
into our medical practice. It should be collected Aug.-Sept., carefully
dried, and sold loosely or in various-sized compressed packages; powder
keeps well.
CONSTITUENTS. -- Lobeline, Lobelacrin, Lobelic acid,
Inflatin, a second alkaloid (?), resin, wax, volatile oil (lobelianin),
fixed oil (seed) 30 p.c., gum, ash 8 p.c.
Lobeline. -- Obtained by evaporating to syrup
the acetic-alcoholic tincture (preferably of seed), triturating this with
magnesium oxide in excess, agitating filtrate with ether, evaporating,
getting impure alkaloid. It is a yellow, aromatic liquid, acrid taste,
convertible into amorphous powder and non-crystalline salts (hydrobromide,
sulphate, etc.) Soluble in water. Dose (sulphate), gr. 1/6-1 (.01-.06
Gm.).
Lobelacrin. -- Obtained by concentrating
tincture in the presence of charcoal, washing with water, exhausting with
boiling alcohol; it is the acrid principle -- possibly lobelate of lobeline,
brown, soluble in ether or chloroform, splitting with dilute acids or alkalies
into sugar and lobelic acid.
Lobelic Acid. -- Obtained by precipitating
decoction of leaves with copper sulphate, and decomposing with hydrogen
sulphide; it is colored olive-brown by ferric salts.
Inflatin. -- Neutral principle (wax), tasteless
crystals, no medicinal value.
PREPARATIONS. -- 1. Tinctura Lobeliae. Tincture
of Lobelia. (Syn., Tr. Lobel.; P. I. Lobeliae tinctura; Fr. Teinture
de Lobelie; Ger. Lobelientinktur.)
Manufacture: 10 p.c. Similar to Tinctura
Veratri Viridis, page 104; menstruum: diluted alcohol. Dose, mv-30
-- 60 (.3-2--4 cc.).
2. Fluidextractum Lobeliae, N.F. (1st menstruum: -- acetic
acid 5 cc., alcohol 50, water 45; 2d -- diluted alcohol), Dose, mj-5 --
20 (.06-.3 -- 1.3 cc.).
Unoff Preps.: Acetum, 10 p.c., mv-60 (.3-4
cc.). Extract, gr. 1/2-2 (.03-.13 Gm.). Infusion, 5 p.c., 3ss-1
(15-30 cc.). Tinctura Lobeliae Aetherea (Br.), 20 p.c. (spirit of
ether), mv-15 (.3-1 cc.). The "Eclectic" lobelin, made in the usual
way, is an impure resinoid, gr. 1/2-1 (.03-.06 Gm.).
PROPERTIES. -- Expectorant, emetic, nervine, purgative,
narcotic, diuretic, diaphoretic; similar to ipecac, but causes more distressing
nausea and intense prostration; it paralyzes the motor nerves,, vasomotor
center, and peripheral vagi. Leaves chewed a short time cause giddiness,
headache, tremors, nausea, vomiting; full doses give speedy and severe
vomiting, general relaxation, cold skin with sweating; resembles tobacco,
is dangerous, having caused many deaths.
USES. -- Spasmodic asthma, catarrh, croup, bronchial
spasms, whooping-cough, in enema for intussusception, strangulated hernia,
constipation -- when feces hard and dry; externally for poison-ivy (oak)
eczema. Should not be given as an emetic, and is too depressing for
children.
Poisoning: Have burning pain in fauces, esophagus,
motor weakness, great depression, feeble pulse, low temperature, anxious,
livid countenance, contracted pupils, vertigo, tremors, cold sweat, pale
skin, sometimes violent purging, collapse, stupor, coma, death from respiratory
failure. Place in recumbent position, empty stomach if vomiting has
not been free, give tannin, cardiac and respiratory stimulants, strychnine,
picrotoxin, thebaine, alcohol, digitalis, atropine or belladonna, digitalis,
morphine, artificial heat, ergot, castor oil.
Incompatibles: Strychnine, picrotoxin; caustic
alkalies decompose lobeline, making preparations inert.
Synergists: Emetics, motor depressants.
1. Lobelia syphilit'ica, Great Lobelia. --
Stem .6-1 M. (2-3 degrees) high; flowers large, 2.5 Cm. (1') long, beautiful
blue; diaphoretic. Used by the aborigines for syphilis.
2. L. Cardina'lis, Cardinal-flower. -- Stem
.6-1.3 M. (2-4 degrees) high; flowers large, showy, intense cardinal or
scarlet-red. Used by Indians as anthelmintic; similar to L. Syphilitica,
but milder.
Lophophora
Lophoph'ora (Anhalo'nium) William'sii (Lewinii),
Mescal(e) Buttons; Mexico. -- This small succulent cactus yields the
mescal buttons (upper layer of turnip-shaped stem, consisting of ovoid
tubercles, dried) which are used by the Rio Grande Indians to produce intoxication
-- similar to cannabis, during religious ceremonies; contain anhalonine
(similar to pellotine), mescaline, anhalonidine, lopophorine. Heart
and respiratory stimulant, tonic, adjuvant to digitalis, narcotic; slightly
slows pulse, produces mental and physical weariness, sleep without untoward
symptoms; excessive quantities produce spasms resembling strychnine poisoning;
pneumothorax, tuberculosis, angina pectoris, asthmatic dyspnea, hysteria.
Dose, (pellotine), gr. 1/2-2 (.03-.13 Gm.); Fluidextract, mv-10 (.3-.6
cc.).
Luffa
Luf'fa Luffa (aegypti'aca), Egypt, and L. Opercula'ta,
Brazil, Vegetable Sponge, Wash-rag Sponge, Gourd Towel. Cu'cumis
myriocar'pus; S. Africa.--These produce analogous fruits, which have similar
action to colcynth, while the derma of Luffa serves as sponge.
Lycium
Lyc'ium vulga're. -- United States, Europe;
L. Af'rum, N. Africa, and L. Umbro'sum, S. America; leaves of all in infusion
good for erysipelas and skin diseases.
Lycopodium
LYCOPODIUM. LYCOPODIUM, U.S.P.
Lycopodium clavatum, Linne'.
The spores.
Habitat. Europe, Asia, N. America,
in dry woods
Syn. Lycopod., Club Moss, Clubfoot
Moss, Running Moss, Snake (Staghorn) Moss, Ground (Running) Pine,
Wolf's Claw, Fox Tail; Vegetable Sulphur (Brimstone), Semen Lycopodii;
Fr. Lycopode, Soufre vegetal, Pied de Loup; Ger. Barlappsporen, Hexenmehl,
Streupulver, Blitzpulvre
Ly-co-po'di-um. L. See etymology, above,
of Lycopodiaceae.
Cla-va'tum. L. clavatus, club-like
-- i.e., alluding to club-like appearance of the fertile spikes.
PLANT. -- Low creeping perennial; stem .6-3 M. (2-10
degrees) long, slender, tough, flexible, woody; branches ascending, leafy,
the fertile terminated by a slender peduncle 10-15 Cm. (4-6') long, with
1-2 linear, cylindrical spikes -- thecae, cones, capsules, 2.5-5 Cm. (1-2')
long; leaves linear, awl-shaped, 6 Mm. (1/4') long, dense, light green,
tipped, as are also the numerous bracts, on the flowering spikes with a
fine bristle; in axils of bracts have the kidney-shaped sporangia containing
the spores. SPORES, a light yellow, very mobile powder, odorless
tasteless; spores shaped like 3-sided pyramid with convex base, .025-.04
Mm. (1/1000-1/625') broad; outer surface reticulate -- reticulations polygonal
and formed by straight-sided delicate ridges, which form a delicate fringe
at edges of spore; viewed with the rounded surface of spore on the under
side, a distinct triangular marking is seen, formed by edges of flat surfaces
of the spore. Tests: 1. Not wetted by water -- floats upon it; when
boiled with water -- sinks, when thrown into a flame -- burns with a quick
flash. 2. Shows very few, if any, pollen grains, .04-.07 Mm. 1/625-1/360')
broad, and consisting of a central convex, generative cell separating two
spherical cells or wings containing air (abs. of pine pollen). 3.
Boiled with water and cooled, + iodine T.S. -- no bluish color (abs. of
starch), or reddish color (abs. of dextrin).
ADULTERATIONS. -- Pine pollen (coarser, less mobile,
mixes more easily with water), starch, flour (sometimes 25 p.c., sinks
in carbon disulphide), dextrin (soluble in water, when concentrated--precipitated
by alcohol), sulphur (dissolves in carbon disulphide, remaining upon evaporation),
rosin (treat with alcohol, evaporate), turmeric (reddish-brown with alkalies),
talc, gypsum, ferruginous earth, sand (increasing ash beyond 3-5 p.c.,
and quickly subsiding when shaken with carbon disulphide, chloroform, or
water).
Commercial. -- Collected, July-August, in
Scandinavia, Baltic lands, Northeastern Poland, Russia, etc., chiefly from
L. clavatum, rarely L. complana'tum (spikes (cones) or sporangia, and spores
of each very similar), by villagers in wooded areas, who sell their product
to local agents, who, after drying it 1-2 weeks, avoiding artificial heat,
shake the spores out through ordinary flour sieves, when it contains 5-10
p.c. of impurities (leaves, scaly fragments, sand, wheat and rye flour,
etc.) Spikes when ripe yield pure spores 23 p.c., when green 10-15
p.c.
CONSTITUENTS. -- Fixed oil 47-49 p.c., cane-sugar
(sucrose) 2 p.c., volatile base (methylamine), ash 3-5 p.c. (sand + 1 p.c.
P2O5). The substance of the cell-wall is called pollenin; when treated
with potassium hydroxide gives yellow color, becoming blue upon the addition
of sulphuric acid and iodine. The oil, similar to expressed oil of
almonds, contains palmitic, stearic, myristic, and oleic acids -- the latter
80 p.c.being slightly abnormal.
PROPERTIES. -- Once considered diuretic, antispasmodic
for rheumatism, epilepsy, pulmonary and renal disorders, dysentery.
USES. -- Externally to protect tender and raw surfaces,
erysipelas, eczema, herpes, ulcers, chafing in infants; in pharmacy as
a basis for insufflations, also to prevent adhering of pills, suppositories,
etc. Popular "homeopathic medicine" (1 to 100 lactose triturated
till oil liberated); internally gives excited circulation, urinary irritation,
often cures dyspepsia, flatulence, constipation, aneurism, diphtheria,
mucous membrane affections of lungs and bronchi.
Lycopus
Ly'copus virgin'icus, Bugle Weed. -- The herb,
U.S.P. 1830-1870; N. America. Plant has smooth, obtusely quadrangular
stem, 15-60 Cm. (6-24') high; leaves 5 Cm. (2') long, elliptic, glandular;
flowers purple, 4-lobed, stamens 2. mint odor and bitter taste, root perennial,
creeping; contains volatile oil, resin, bitter principle, tannin.
Astringent, tonic, sedative, narcotic; hemorrhage, diarrhea, dysentery;
infusion, decoction. Dose, gr. 5-30 (.3-2 Gm.).
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