A Manual of Materia Medica
and Pharmacology
by David M. R. Culbreth, Ph.G., M.D. (1927)
Jateorhiza
CALUMBA. CALUMBA, U.S.P.
Jateorhiza palmata, (Lamarck) Miers.
The dried root yielding not more than 2.5 p.c. of acid-insoluble ash.
Habitat. E. Africa, Madagascar (Mozambique
and Quilimane forets, along the lower Zambesi River); cultivated
in Africa and E. India islands.
Syn. Calumb., Columba, Columbo, (Foreign)
Colombo, Kalumb.; Br. Calumbae Radix; Fr. Colombo, Racine de Colombo
(Calumbe); Ger. Radix Colombo, Kolombowurzel.
Jat-e-o-rhi'sa. L. fr. Gr...., healing,
+ ..., a root -- i.e., its medicinal virtues.
Pal-ma'ta. L. Palmatus, like the palm
of the open hand with radiating fingers (segments) -- i.e., the leaves
palmately-lobed or divided.
Ca-lum'ba. L. fr. native African name,
kalumb, hence Colombo in Ceylon, supposed to be the plant's original habitat.
PLANT. -- Perennial climber; stems several, green,
6-12 Mm. (1/4-1/2') thick, hairy, from short, thick, irregular rhizome;
leaves petiolate, large, 25 Cm. (10') long, 35 Cm. (14') broad, orbicular,
cordate, 3-5-7-palmately-lobed, lobes entire, wavy, hairy; flowers dioecious,
6's, 12 Mm. (1/2') broad; fruit 3 ovoid fleshy drupes, size of hazelnut,
1-seeded. ROOTS, from rhizome, many fleshy, fasciculated, fusiform;
commercially in circular, oval disks up to 10 Cm. (4') and seldom exceeding
2 Cm. (4/5') thick, or longitudinal, oblique slices up to 30 Cm. (12')
long; edge brown, roughly wrinkled, cut surfaces yellowish-brown, grayish-yellow,
transverse slices radiate in outer portion with dark cambium, center often
depressed (thinnest); fracture short, mealy; odor slight; taste slightly
aromatic, very bitter. POWDER, greenish-brown, grayish-yellow--many
starch grains, .003-.085 Mm. (1/8325/1/300') broad, few stone cells with
one or more calcium oxalate prisms or sphenoidal microcrystals; few fragments
with tracheae associated with wood-fibers. Solvents: alcohol (75
p.c.); boiling water largely (calumbin, berberine). Dose, gr. 5-30
(.3-2 Gm.).
ADULTERATIONS. -- Roots of Bryonia alba and Frasera
carolinensis (Walteri) -- American Columbo. These sometimes are dyed
yellow with turmeric or safflower, and made bitter with infusion of calumba
or quassia, thus giving a near resemblance, but recognized by the lighter
or slightly false color, absence of dark cambium zone, radiating lines,
etc.; the latter also precipitates with iron salts, is not mucilaginous
nor affected by infusion of galls, reddens litmus, evolves ammonia with
fixed alkalies, and contains no starch. Occasionally with slices
of the stem of Coscin'ium fenestra'tum, Ceylon, which are harder, smoother,
and not contracted centrally; false calumba -- center elevated, not depressed.
Commercial. -- Plant, also named Menispermum
palmatum, Boc'culus palma'tus, and natively called Kalumb, resembles very
closely our Menispermum canadense, reaching the top of lofty forest trees
from the seacoast to many miles inland. Roots of wild plants are
dug in hot dry season (March), tubercles separated, washed, cut into transverse
and longitudinal slices, and dried slowly in the shade; often more or less
worm-eaten. Portuguese always have controlled (1508) its trade, exporting
it for 3 centuries via Colombo, Ceylon, also their possession to veil its
origin; now enters market from Zanzibar, or via Bombay.
CONSTITUENTS. -- Calumbin .8 p.e., Berberine 1 p.c.,
Calumbic acid, calumbine (?), starch 35 p.c., pectin 17 p.c., gum 4.7 p.c.,
resin 5 p.c., wax, calcium oxalate, ash 6-8 p.c.
Calumbin, C21H24O7.
-- Gives most of the bitterness -- obtained by exhausting root or alcoholic
extract with alcohol or ether, evaporating and letting stand several days
for crystals to form, which are white, bitter, odorless, soluble in alcohol,
ether, chloroform, alkalies, acetic acid, almost insoluble in water.
Dose, gr. 1/2-1 (.03-.06 Gm.).
Berberine, C20H17O4N.
-- This is left in mother-liquor from calumbin, which is evaporated to
dryness, exhausted with boiling alcohol, evaporated, allowed to crystallize
upon standing. Recently this content has been resolved into three
alkaloids -- palmatine, calumbamine, jateorhizine -- which with calumbin
constitute the drug's activity. Dose, gr. 1/2-1 (.03-.06 Gm.).
Calumbic Acid, C221H22O6.H2O.
-- Obtained from 3 p.c. oxalic acid infusion by adding barium hydroxide
and treating precipitate with alcohol; it is less bitter than calumbin,
amorphous, straw-yellow, soluble in alcohol, alkalies, almost insoluble
in water or ether, and is in combination with berberine -- the two believed
to be derived from calumbin, this latter being the anhydride of calumbic
acid.
Calumba contains no tannin, hence can well be used
with iron salts and alkalies as a substitute for gentian, etc.; its infusion
or tincture, however, precipitates with infusion of galls or solution of
lead acetate.
PREPARATIONS. -- 1. Tinctura Calumbae. Tincture
of Calumba (Syn., Tr. Calumb., Tinctura Colombo; Fr. Teinture de Colombo;
Ger. Kolombotinktur.)
Manufacture: 20 p.c. Similar to Tinctura
Veratri Viridis, page 104 -- packing moderately; menstruum: 60 p.c. alcohol.
Dose 3ss-2 (2-8 cc.). 2. Fluidextractum Calumbae, N.F. (67 p.c. alcohol).
Dose, mv-30 (.3-2 cc.). Extract, gr. 1-5 (.06-.3 Gm.). Infusion,
5 p.c., 3ss-1 (15-30 cc.).
PROPERTIES. -- Tonic, stomachic, stimulant, increases
appetite and digestion by stimulating the gustatory nerves, thereby dilating
the gastric vessels and augmenting secretion, does not constipate; externally--antiseptic,
disinfectant, anthelmintic.
USES. -- Dyspepsia, debility, remittent fevers,
dysentery, diarrhea, cholera morbus, cholera infantum, hectic fever of
phthisis, vomiting of pregnancy, bowel flatus, purging; large doses emeto-cathartic.
Jateorhiza calumba
Jateorhiza Calumba. -- About the same as the
official, possibly having a variety difference in that the basal lobes
of leaves are rounded but do not overlap, and male inflorescence is hispid.
In the official variety, basal lobes mostly overlap, and male infloresence
is smooth. Our commercial root is collected indiscriminately from
both species.
Juglans
Ju'glans cine'rea, Juglans, Butternut Bark, N.F.
-- Juglandaceae. -- The dried inner bark of the root, with not more than
2 p.c. of adhering wood or other foreign organic matter; United States,
Canada. Handsome spreading tree, 9-15 M. (30-50 degrees) high, light
gray bark, durable brown wood; leaves imparipinnate; flowers -- staminate
and pistillate; fruit large, oblong drupe, 6 Cm. (2 2/5') long, hairy,
viscid, green then brown; seed thick, oily, edible. Root-bark (liber)
in quills, curved strips, chips, 3-10 Mm. (1/8-2/5') thick, deep brown
throughout, outer surface smooth, warty, inner surface smooth, striate;
fracture short, weak; odor faintly aromatic; taste bitter, astringent,
acrid. Powder, dark brown -- calcium oxalate rosette crystals, starch
grains, stone cells, sometimes with reddish content, crystal-fibers, tannin,
oily drops; contains juglandic acid (juglone, nucin -- oxynaphtoquinone),
fixed oil 14 p.c., volatile oil, resin, tannin, ash 8 p.c. Cathartic
(resembling rhubarb), mild hepatic stimulant; malaria, chronic constipation,
dysentery. Dose, 3j-2 (4-8 Gm.); 1. Fluidextractum Juglandis (lst
menstruum: glycerin 10, alcohol 50, water 40; 2d diluted alcohol): Prep.:
1. Elixir Cascarae Sagradae Compositum, 6.5 p.c. Juglandin ("Eclectic"
resinoid), gr. 3-10 (.2-.6 Gm.).
J. re'gia, English Walnut. -- Persia, Himalayas,
China, cultivated, Europe. Decoction of leaves used in leucorrhea,
meningitis; decoction of leaves, rind, or bark in checking mammary secretion,
ulcers, diarrhea, sore mouth, tonsils, uterine hemorrhages, carbuncles.
J. ni'gra, Black Walnut.--Bark styptic, acrid; used mostly in dyeing.
The rind of green fruit removes ringworms, tetter, diphtheria. Decoction
used as a vermifuge; spirit made by distilling fresh walnuts with alcohol;
used in hysteric, cerebral and pregnant vomiting. All of these fruits
contain much fixed oil, which turns red with nitric acid, but brown with
nitric and sulphuric acids.
Juniperus communis
JUNIPERUS. JUNIPER BERRY, N.F.
Oleum Juniperi. Oil of Juniper, U.S.P.
Juniperus communis, Linne'. A
volatile oil distilled from the dried ripe fruit.
Habitat. N. America (Canada, N. United
States), Asia, Europe, N. Africa; dry woods, hills.
Syn. Juniper Bush, Juniper Berries,
Fructus (Bassae) Juniperi; Fr. Genievre, Baies de Genievre; Ger.
(Gemeiner) Wachholderbeeren; Ol, Junip., Juniper Oil, Oil of Juniper
Berries, Oleum Fructus (Baccae) Juniperi, Fr. Essence de Genievre; Ger.
Wachholder (beer) ol.
Ju-nip'e-rus. L. fr. Celtic juniperus,
rough -- i.e., its foliage; or fr L. Juvenis, young, + parere, to
produce -- i.e., young fruit, leaves, etc., are continually replacing the
old.
Com-mu'nis. L. common, general -- i.e.,
the usual or ordinary kind.
PLANT. -- Evergreen shrub 2-5 M. (6-15 degrees)
high, with many close branches, some often prostrate; leaves narrow, longer
than fruit, 12 Mm. (1/2') long, in whorls of 3's, sharp-pointed, channeled,
deep green; flowers dioecious -- staminate catkins, pistillate cones.
Fruit (galbulus) -- Juniperus, Juniper Berry, N.F. The carefully
dried ripe fruit with not more than 10 p.c. of immature or discolored berries
and 3 p.c. of foreign organic matter. It is nearly globular, 8 Mm.
(1/3') thick, blackish-purple, blue-gray bloom, apex 3-furrowed -- cohesion
of 3 fleshy bracts; internally loosely fleshy, many schizogenous cavities,
3 ovate seed, oil-glands on surface, ripens second year; odor aromatic;
taste sweet, pleasant, terebinthinate, bitter. Powder, dark brown
-- stone cells, calcium oxalate prisms, polygonal cells, aleurone grains,
oil globules, resin masses.
CONSTITUENTS. -- Volatile oil .5-2.5 p.c., sugar
15-30 p.c., resin 10 p.c., juniperin, proteins 4 p.c., fat, wax, malates,
formic and acetic acids.
Oleum Juniperi. Oil of Juniper. -- Obtained from the dried
ripe fruit by distillation with salt and water, or steam; it is a colorless,
faintly green or yellow liquid, characteristic odor and taste of juniper
berries, soluble in 4 vols. of alcohol with not more than slight cloudiness,
neutral, slightly acid, sp. gr. 0.870, levorotatory; contains chiefly pinene,
C10H16, with some cadinene, C15H24,
juniper camphor, and an ester to which odor and taste are due. Should
be kept cool, dark, in well-stoppered, amber-colored bottles. Dose,
mv-15 (.3-1 cc.).
PREPARATIONS. -- BERRY: 1. Fluidextractum
Juniperi, N.F. (80 p.c. alcohol), dose, 3j-2 (4-8 cc.): Prep.: 1. Elixir
Buchu, Juniperi et Potassi Acetatis, N.F., 7.5 p.c. 2. Fluidextractum
Buchu Compositum, N.F., 12.5 p.c.: Prep.: 1. Elixir Buchu Compositum, N.F.
25 p.c. Extract: Infusion; Succus Juniperi Inspissatus (Ger.), 20 p.c.
OIL: 1. Acetum Aromaticum, N.F., 1/20 p.c. Spirit, 5 p.c. + alcohol, 3j-4
(4-15 cc.). Compound Spirit, 2/5 p.c. -- oil of juniper 2/5 p.c.,
oil of caraway 1/20, oil of fennel 1/2, 70 p.c. alcohol q.s. 100 cc., 3j-4
(4-15 cc. -- substitute for gin.).
PROPERTIES. -- Similar to turpentine; stimulant,
diuretic, anodyne, emmenagogue, carminative, stomachic, antiseptic.
USES. -- Renal dropsy, vesical catarrh, rheumatic
pains, swellings.
Juniperus oxycedrus
JUNIPERUS OXYCEDRUS. PRICKLY CEDAR.
Oleum Cadinum. Oil. of Cade, U..S.P.
Juniperus oxycedrus, Linne'.
An empyreumatic volatile oil obtained from the wood.
Habitat. S. Europe, Spain.
Syn. Prickly (Spanish, Berry-bearing)
Cedar, Large Brown-fruited Juniper; Ol. Cadin., Cade Oil, Oil of
Juniper Tar, Oleum Juniperi Empyreumaticum (Nigrum); Fr. Huile de
Cade; Ger. Kadeol, Takinol, Spanisch-Cederol.
Ox-y-ce'drus. L. fr. Gr...., sharp,
pointed, + ..., cedar -- i.e., cedar with pointed leaves.
Ca-di'num. L. fr. Fr. Cade, juniper;
Bohem. Kadik, juniper -- i.e., European cedar.
PLANT. -- Shrub 2.4-3.7 M. (8-12 degrees) high,
resembling J. commu'nis, branches spreading, drooping; leaves medium
size, awl-shaped, pointed, 2 furrows on upper edge; fruit 12 Mm. (1/2')
thick, reddish, shining, 2 white lines on apex.
CONSTITUENTS. -- Volatile oil, resin, tannin, extractive
(acetic acid, pyroligneous acid, acetone, methyl alcohol, etc.)
Oleum Cadinum. Oil of Cade. -- Should be dry (downward)
distilled from the heartwood, similar to obtaining tar, pieces of wood
being laid carefully upon one another and covered with earth except an
opening at the top, thus permitting slow combustion; inverted iron pots
also are filled with billets, surrounded with worthless wood and set on
fire, producing sufficient heat for distillation; product is caught in
receptacles, set aside 15-20 days for separation of tarry and aqueous layers,
the upper oily one constituting the commercial product. It is a dark
brown, clear, thick liquid, tarry odor, warm, faintly aromatic, bitter
taste, slightly soluble in water, imparting to it acid reaction, partially
soluble in alcohol, petroleum benzin, completely soluble in ether (3),
amyl alcohol, chloroform, glacial acetic acid, oil of turpentine, sp. gr.
0.980-1.055; contains phenols and sesquiterpene -- cadinene, C15H24.
Test. 1. Shake 1 part with warm distilled water (20); filtrate, +
3 drops of ferric chloride solution (1 in 1000) -- red; or + silver ammonium
nitrate T.S. -- blackens (cold); or + alkaline cupric tartrate T.S. (hot)
-- red precipitate. Impurities: Rosin, rosin oil. The oil from
wood of J. Communis often substituted. Dose, miij-5 (.2-.3 cc.)
PREPARATIONS. -- 1. Petroxolinum Cadinum,
N.F., 25 cc. In 100 cc. of product. 2. Linimentum Saponis Mollis
Compositum, N.F., 2 p.c. 3. Petroxolinum Sulphuratum Compositum,
N.F., 10 cc. In 100 cc. of product. 4. Unguentum Sulphuris Compositum,
N.F., 15 p.c.
PROPERTIES. -- Anthelmintic, externally parasiticide.
USES. -- Psoriasis, pityriasis rubra, chronic eczema,
prurigo, psora, favus. This oil may replace the U.S.P. Oleum Picis
Rectificatum, both having the same effect.
Juniperus sabina
Juniperus Sabi'na, Savin, Shrubby Red Cedar.
-- The tops, U.S.P. 1820-1900; Europe, Siberia, N. America, rocky banks,
mountains. Evergreen shrub, procumbent or erect, 1-4.5 M. (3-15 degrees)
high, branched, bark greenish (young), brownish (old); flowers dioecious;
fruit galbulus, bluish, size of a pea, 1-3-seeded. Tops yellowish-green,
sub-quadrangular branchlets; leaves 4 rows, dark green, scale-like, ovate-lanceolate,
acute, imbricated, shallow groove on back, roundish gland in middle; odor
peculiar terebinthinate; taste disagreeable, resinout, bitter; solvents:
boiling water, alcohol; contains volatile oil 2-5-10 p.c., resin, tannin,
salts (K, Ca). Diuretic, emmenagogue, ecbolic, irritant, hemagogue;
amenorrhea, dysmenorrhea, menorrhagia, rheumatism, gout; warts, ulcers,
dental caries, tinea capitis, polypi. Poisoning: Abdominal pain,
vomiting, strangury, convulsions, coma -- magnesium sulphate (full dose),
demulcents, anodynes, stimulants. Dose, gr. 5-15 (.3-1 Gm.), in syrup,
honey; fluidextract (alcohol), mv-15 (.3-1 cc.); cerate 25 p.c.), to prolong
secretion from blisters, etc.; Infusion, Tincture.
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