MEDICAL RESEARCH ON THE
Edgar Cayce is not alone in recognizing the that
toxins leaking form the intestines are involved in psoriasis. The
technical term for leaky intestines is "intestinal permeability."
Several researchers have written on this subject in the medical journals.
Here is a brief summary of that literature.
Humbert et al. (1991) noted, "A possible
relationship between intestinal structure and function in the pathogenesis
of psoriasis has recently brought about considerable interest." They
studied the intestines of 15 psoriatic patients and 15 healthy subjects
and concluded, "The difference in intestinal permeability
between psoriatic patients and controls could be due
to alterations in the small intestinal epithelium of psoriatics" (p. 324).
Person and Bernhard (1986), noted that the "pustular
dermatitis associated with small bowel bypass surgery and the
cutaneous manifestations of inflammatory bowel disease are well known
and generally assumed to be due to the absorption
of microbial antigens from the bowel." They hypothesized
that the association of intestinal and dermatological pathology "may be
the result of minor perturbations of mucosal permeability or
the failure of locally produced dimeric serum
IgA to inactivate bacterial or dietary antigens.
Such disparate entities as Reiter's syndrome,
psoriasis, pyoderma gangrenosum, and ankylosing
spondylitis, as well as the pustular
eruptions of Behcet's syndrome, pustular psoriasis,
and lithium therapy, may share
this common pathogenesis" (p.559). This particular research
approach is an excellent example of co-morbidity and nonspecificity.
In other words, the same cause may produce a variety of symptoms and syndromes.
Yates, Watkinson and Kelman (1982) also noted
co-morbidity and nonspecificity in an article entitled, "Further
evidence for an association between psoriasis, Crohn's disease
and ulcerative colitis." To test the hypothesis that these three
illnesses are related, they studied 204 patients with inflammatory bowel
disease (116 with Crohn's disease and 88 with ulcerative colitis) and 204
age and sex matched controls. Although their research did not directly
address the question of intestinal permeability, they did conclude: "The
prevalance of psoriasis in Crohn's disease (II.2%) and in ulcerative colitis
(5.7%), was significantly greater than in the control group (1.5%). The
prevalence of psoriasis in first degree relatives of patients with inflammatory
bowel disease was also increased. It is suggested that there is a
relationship between psoriasis, ankylosing spondylitis, sacroiliitis, peripheral
arthropathy and inflammatory bowel disease, which may be explained by common
genetic factors. (p. 323)"
REFERENCES AND SELECTED BIBLIOGRAPHY
Barry, R. E., Salmon, P. R., Read, A. E. &
Warin, R. P. (1971). Mucosal architecture of the small bowel
in cases of psoriasis. Gut, 12(11), p873-7.
Barry, R. M., Salmon, P. R. & Read, A. E.
(1971). Small bowel mucosal changes in psoriasis. Gut, 12(6), p495.
Bedi, T. R., Bhutani, L. K., Kandhari, K. C. &
Tandon, B. N. (1974). Small bowel in skin diseases. Indian
Journal of Medical Research, 62(1), p142-9.
de Vos, R. J., de Boer, W. A. & Haas,
F. D. (1995). Is there a relationship between psoriasis and
coeliac disease? Journal of Internal Medicine, 237(1), p. 118.
Fry, L. (1970). The gut and the skin.
Postgraduate Medical Journal, 46(541), p664-70.
Humbert, P., Bidet, A., Treffel, P., Drobacheff,
C. & Agache, P. (1991). Intestinal permeability in patients
with psoriasis. Journal of Dermatological Science, 2(4), p.324-6.
Madanagopalan, N., Shantha, M., Rao, U. P. &
Thambiah, A. S. (1973). Peroral jejunal mucosal biopsy
in dermatological and some non-diarrhoeal diseases. Australian Journal
of Dermatology, 14(1), p47-52.
Marks, J. & Shuster, S. (1971).
Intestinal malabsorption and the skin. Gut, 12(11), p938-47.
Marks, J. & Shuster, S. (1971).
Psoriatic enteropathy. Archives of Dermatology, 103(6), p676-8.
Moll, J. M., Haslock, I., Macrae, I. F. &
Wright, V. (1974). Associations between ankylosing
spondylitis, psoriatic arthritis, Reiter's disease, the intestinal
arthropathies, and Behcet's syndrome. Medicine, 53(5), p343-64.
O'Laughlin, J. C. & Di Giovanni, A. M.
(1979). Psoriatic enteropathy: report of case and review of literature.
Journal of the American Osteopathic Association, 79(2), p107-11.
Person, J. R. & Bernhard, J. D. (1986).
Autointoxication revisited. Journal of the Americal Academy of Dermatology,
Salmon, P. R., Read, A. E. & Warin, R.
(1969). Radiocarbon estimation of lactose absorption:
a survey of 104 patients with skin disease. Gut, 10(12), p1052.
Shuster, S. (1968). Dermatogenic
enteropathy. New York State Journal of Medicine, 68(24), p3160-5.
Summerly, R. & Giles, C. (1971).
Question of psoriatic enteropathy. Archives of Dermatology, 103(6),
Yates, V. M., Watkinson, G. & Kelman, A.
(1982). Further evidence for an association between
psoriasis, Crohn's disease and ulcerative colitis. British Journal
of Dermatology, 106(3), p323-30.